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Aside from Zipline, there are a number of algorithmic trading libraries in various stages of development for Python. From the commercial side, RapidQuant looks very interesting though I haven't tried it yet. It's from some of same developers that brought us the excellent Pandas data analysis library. I think Wes McKinney (Pandas's main author) is ...
You can have a look at : TradingWithPython library (TWP Library) http://www.tradingwithpython.com/. Like Quantopian / Zipline it uses Python Pandas library. It includes an Interactive Brokers module to trade realtime.
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