If by order flow you mean high-frequency changes in prices, returns, volume, and other variables based on intraday data at various levels of market depth, yes there are various approaches that have been developed, typically falling under two categories: behavioral approaches, which try to model order flow by simulating trader behavior, often with agent-based models that entail unrealistic assumptions, and statistical approaches which rely on quantitative measures that often take into account averaged tick-by-tick distributions of the limit order book variables by using order data besides the target variable for features. The Poisson process is a common but naive starting point for modeling order flow. Order flow can mean any one of a number of variables taken or derived from the order book though, so it will all depend on which one you want to anticipate. Quantatative finance publishes research on order book models.

If by order flow you mean high-frequency changes in prices, returns, volume, and other variables based on intraday data at various levels of market depth, yes there are various approaches that have been developed, typically falling under two categories: behavioral approaches, which try to model order flow by simulating trader behavior, often with agent-based models that entail unrealistic assumptions, and statistical approaches which rely on quantitative measures that often take into account averaged tick-by-tick distributions of the limit order book variables by using order data besides the target variable for features. The Poisson process is a common but naive starting point for modeling order flow. Order flow can mean any one of a number of variables taken or derived from the order book though, so it will all depend on which one you want to anticipate. Quantitative finance publishes research on order book models.