In general these are the two basic approaches to QuantFinance:
Sell side (market maker, risk neutral): You use risk-neutral probabilities ("$\mathbb{Q}$") e.g. in option pricing (to e.g. calculate your greeks and hedge your portfolio), so that you live on the spread.
Buy side (market/risk taker): You use real-world probabilites ("$\mathbb{P}$") for e.g. trading strategies.
See also this excellent article:
'P' Versus 'Q': Differences and Commonalities between the Two Areas of Quantitative Finance by Attilio Meucci.
From the abstract:
There exist two separate branches of finance that require advanced
quantitative techniques: the "Q" area of derivatives pricing, whose
task is to "extrapolate the present"; and the "P" area of quantitative
risk and portfolio management, whose task is to "model the future."
We briefly trace the history of these two branches of quantitative
finance, highlighting their different goals and challenges. Then we
provide an overview of their areas of intersection: the notion of risk
premium; the stochastic processes used, often under different names
and assumptions in the Q and in the P world; the numerical methods
utilized to simulate those processes; hedging; and statistical
arbitrage.