As Alex C says in the comments, Longstaff and Schwarz did consider multiple factors and mention it as one of the advantages (page 114 in the journal):
By its nature, simulation is a promising alternative to traditional finite difference and binomial techniques and has many advantages as a framework for valuing, risk managing, and optimally exercising American options. For example, simulation
is readily applied when the value of the option depends on multiple factors.
Emphasis mine. Disadvantages that spring to mind are that the method
- Is a Monte Carlo method which implies that results will have a simulation error;
- It is a priori unclear what kind of basis function work best and how many are needed for performing the least squares regression with success.
On the upside, the diagnostic test described on pages 127 and 128 can be used when testing whether the parameters one chooses work well for the problem at hand.